Via Lore Sjöberg, I recently discovered Basic Instructions. Basic Instruction's high concept is that each strip presents a simple how-to lesson, such as how to give directions or how to plan a vacation. The visual style is very simple; it's all black-and-white and appears to consist of a handful of original pieces of art that the author copies, pastes, and photoshops to suit the framing needs of each panel. The comic makes up for its lack of visual style with deft wit, and Scott Meyer manages a nice mixture of observational and absurdist humor.
I'm not Eric Burns, so I can't write a 10,000 word essay on the literary and rhetorical significance of the main character's goatee, so instead I'll just link to a few favorite strips:
How to train your back-up
How to apply the laws of physics to personal relationships
How to apologize without accepting any blame
